Skip to main content
. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2008 Sep;7(9):2725–2735. doi: 10.1158/1535-7163.MCT-08-0573

Figure 6.

Figure 6

Peri-implantational Hedgehog blockade is sufficient to cause in vivo growth inhibition of pancreatic cancer xenografts. A, treatment scheme used: Hedgehog signaling in pancreatic cancer cell lines was suppressed by treatment with IPI-269609 in vitro for 3 d. At the same time, continuous application of IPI-269609 to nude mice using s.c. osmotic pumps was initiated and continued for another 4 d after implantation of tumor cells. Mock treatment with solvent only was used as control, and only cell suspensions with >95% viable cells were used for injection. S.c. tumor growth was measured 1 and 2 wk after cancer cell injection. Pretreatment with IPI-269609 led to significantly reduced growth of s.c. E3LZ10.7 and xenografts in nude mice (B; n = 6 per group). **, P < 0.01.