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. 2008 Dec 31;3(12):e4099. doi: 10.1371/journal.pone.0004099

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The cell-type specificity of each line was tested by crossing to the Z/AP reporter and inducing sparse recombination with 4HT. A, In the retina, the NFL-IRES-CreER line exhibits Cre-mediated recombination in retinal ganglion cells, each of which has a single axon projecting to the optic disc, and in horizontal cells; the image shown here shows only retinal ganglion cells. B, in the brain, the VAMP2-IRES-CreER line exhibits Cre-mediated recombination in both neurons and glia. C and D, in the retina, the ChAT-IRES-CreER line exhibits Cre-mediated recombination exclusively in cholinergic (starburst) amacrine cells. The region boxed in C is shown at higher magnification in D. Scale bars: 0.5 mm in A and B; 1 mm in C.