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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Transl Res. 2008 Oct 11;152(5):213–224. doi: 10.1016/j.trsl.2008.09.002

Figure 1. Intravenous S1P administered subsequent to injury reduces shunt formation and bronchoalveolar lavage (BAL) protein accumulation in a canine model of intrabronchial LPS-induced lung injury.

Figure 1

Panel A depicts the evolution of venous admixture (Qs/Qt) in anesthetized beagles subject to high tidal volume mechanical ventilation after intrabronchial administration of bacterial LPS (2–4 mg/kg, black squares, n=9) or intrabronchial LPS plus intravenous S1P one hour later (85 μg/kg, gray circles, n=9). Beagles receiving S1P demonstrated significant reductions in shunt formation beginning 5.5 hours after LPS instillation compared to those receiving LPS alone. Panel B depicts the time-dependent accumulation of protein in the BAL fluid of anesthetized beagles subject to high tidal volume mechanical ventilation after intrabronchial administration of bacterial LPS (2–4 mg/kg, black bars, n=9) or intrabronchial LPS plus intravenous S1P one hour later (85 μg/kg, gray bars, n=9). Mean ± SEM, *p≤0.05 LPS compared to LPS+S1P, † p≤0.05 compared to 90 min, ‡p<0.05 compared to baseline, ††p<0.05 compared to baseline, 3, and 5 hr. Qs/Qt is significantly elevated relative to baseline for all t ≥30 min.