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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Transl Res. 2008 Oct 11;152(5):213–224. doi: 10.1016/j.trsl.2008.09.002

Figure 5. Intravenous S1P administered subsequent to injury augments systemic inflammatory cytokine production in a canine model of intrabronchial LPS-induced lung injury.

Figure 5

Depicted are the time-dependent productions of KC (panel A), IL-8 (panel B), TNF-α (panel C), IL-6 (panel D), MCP-1 (panel E), and IL-10 (panel F) in serum from anesthetized beagles subject to high tidal volume mechanical ventilation after intrabronchial administration of LPS (2–4 mg/kg, black squares, n=6) or intrabronchial LPS plus intravenous S1P one hour later (85 μg/kg, gray circles, n=6). Intravenous S1P augmented the systemic production of KC, TNF-α, and IL-6 induced by intrabronchial LPS compared to LPS alone with no significant alterations in the production of IL-8, MCP-1, or IL-10. Mean ± SEM, *p≤0.05 between groups.