Example of an image for which there was substantial disagreement. One grader scored both tortuosity and dilation as sufficient for plus disease, one graded both tortuosity and dilation as sufficient for pre-plus disease, and one graded tortuosity as sufficient for pre-plus disease and dilation as normal. Therefore, overall eye grades were plus disease for one grader, pre-plus disease for one grader, and neither plus nor pre-plus for one grader. (Image courtesy of the PHOTO-ROP Study Group)