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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Clin Cancer Res. 2008 Dec 15;14(24):8070–8079. doi: 10.1158/1078-0432.CCR-08-0566

Figure 4. cPLA2-α inhibition reduces cyclin D1 and Akt expression in prostate cancer cells.

Figure 4

Figure 4

(A) LNCaP cells were treated with vehicle (Control) or increasing concentrations of Wyeth-1 for 24 hours. Cellular lysate protein (50 μg/lane) was analyzed by Western blot. Reduced levels of p-Akt and cyclin D1 were detected at concentrations of IC50. Reduced levels of t-Akt were detected at IC75. (B) LNCaP cell was treated with increasing concentrations of Wyeth-1. The cell was then paraffin fixed and stained for cyclin D1. LNCaP exhibited reduced numbers of cells positive for Cyclin D1 with increasing Wyeth-1 concentrations. (C) The percentage of Cyclin D1 positive cells with increasing concentration of Wyeth-1. (*p<0.05)