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. Author manuscript; available in PMC: 2008 Dec 19.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2008 Jun 5;28(8):1454–1461. doi: 10.1161/ATVBAHA.107.159392

Figure 4.

Figure 4

S1P differentially regulates SMC differentiation marker gene expression and c-fos by select S1P receptors. A and B, Transiently transfected SMCs were pretreated with VPC25239 (1.0 µmol/L, S1P1/S1P3 antagonist) or JTE013 (1.0 µmol/L, S1P2 antagonist) and stimulated with S1P (1.0 µmol/L) for 24 hours. Pharmacological inhibition of the S1P1 and S1P3 receptors potentiated S1P-induced activation of the SMα-actin and SMMHC promoter-luciferase construct whereas inhibition of the S1P2 receptor prevents S1P-induced activation of SMα-actin and SMMHC promoter-luciferase activity. *P<0.05 compared to veh; #P<0.05 compared to S1P treatment.