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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Cancer Res. 2008 Dec 15;68(24):10377–10386. doi: 10.1158/0008-5472.CAN-08-1444

Figure 5.

Figure 5

Ability of non-EMT, EMT, and MET cells to establish lung metastasis from intravenous inoculation. A, All the animals (n=6) developed lung metastases from intravenous inoculation of vector transfectants (non-EMT cells) as shown by macro photos and H&E staining at both low and high magnifications. None of the animals developed lung metastasis from intravenous inoculation of p12 transfectants (EMT cells) and E-cadherin re-expressed p12 transfectants (MET cells). B, Western blotting analysis of E-cadherin confirmed E-cadherin re-expression. C, E-cadherin re-expression reverted the fibroblastoid structures of p12 transfectants to epithelial structures, suggesting an MET process.