Table 6.
Unadjusted/Univariate-Adjusted/Multivariable-Adjusted Spearman Correlation Coefficients Between Hormonal Variables, Bone Formation Markers, and Bone Resorption Markers With Aortic Calcification per 2.5-mm CT Slice in Rochester, Minnesota, Women Combined and Stratified by Menopausal Status
|
All women |
Premenopausal |
Postmenopausal |
|||||||
| U | A | A/B/C | U | A | A/B/C | U | A | A/B/C | |
| Hormonal variables | |||||||||
| Bio E2 (pg/ml) | −0.49* | 0.13 | 0.08 | 0.23† | 0.22† | 0.12 | −0.17† | 0.06 | 0.09 |
| Bio T (ng/dl) | 0.04 | 0.22* | 0.16† | 0.32‡ | 0.42* | 0.21 | −0.07 | 0.10 | 0.12 |
| PTH (pM) | 0.12 | −0.00 | −0.05 | 0.14 | 0.09 | −0.06 | −0.02 | −0.03 | −0.02 |
| 25-Hydroxyvitamin D (ng/ml) | −0.17‡ | −0.19‡ | −0.16† | −0.19 | −0.21 | −0.17 | −0.14 | −0.17† | −0.18† |
| 1,25-Dihydroxyvitamin D (pg/ml) | −0.20‡ | −0.09 | −0.07 | −0.07 | −0.11 | −0.04 | −0.15 | −0.11 | −0.12 |
| IGF-1 (ng/ml) | −0.42* | −0.09 | −0.07 | −0.30‡ | −0.16 | −0.09 | −0.29* | −0.13 | −0.12 |
| IGFBP-3 (ng/ml) | −0.41† | 0.07 | 0.07 | −0.05 | 0.03 | 0.04 | −0.14 | 0.01 | 0.03 |
| Bone formation markers | |||||||||
| Bone alkaline phosphatase (U/liter) | 0.37* | 0.21‡ | 0.19‡ | 0.31‡ | 0.35‡ | 0.24† | 0.11 | 0.11 | 0.12 |
| Osteocalcin (ng/ml) | 0.07 | −0.03 | 0.02 | −0.24† | −0.12 | −0.08 | −0.02 | −0.00 | 0.02 |
| PINP (μg/liter) | −0.01 | 0.01 | 0.02 | −0.09 | 0.01 | 0.03 | −0.14 | 0.02 | 0.01 |
| Bone resorption markers | |||||||||
| Serum CTX (ng/ml) | 0.13† | −0.03 | 0.00 | −0.14 | −0.05 | −0.04 | −0.05 | −0.01 | −0.01 |
| Urine NTX (nM GF) | 0.20‡ | 0.02 | 0.03 | 0.04 | 0.09 | −0.02 | 0.01 | 0.02 | 0.03 |
* p < 0.001.
† p < 0.05.
‡ p < 0.01.
U, unadjusted; A, age adjusted; A/B/C, age, BMI, cigarette smoking status (ever) adjusted.