Figure 4. Increased risk of the thrombin burst in patients with low flow bypass grafts.

Most patients showed at least some increase in F1.2 in the coronary sinus vs. the aortic blood after OPCAB. However, the “thrombin burst”, defined as a two-fold or greater transcardiac increase in F1.2, was noted in only 18 (30%) patients. Mean blood flow within the venous grafts was significant reduced in those patients who developed the thrombin burst at the end of the case compared to those with F1.2 levels less than this threshold.