Figure 4.

Detection of Msx2 and Dlx3 transcripts in odontogenic tumors by ISH. Analysis of the epithelial (Ep) and mesenchymal (Ms) compartments of the tumors showed that Msx2 transcripts are not expressed in some tumors as shown for ameloblastoma 3 (A), ameloblastoma 6 (B), and the CCOC (D). However, these transcripts were detected in the peripheral non-tumoral cells of ameloblastoma 3 and 6 (A,B, inset) and only in the epithelial compartment of ameloblastoma 4 (C). Concerning the Dlx3 transcript, it was always detected in the epithelial compartments of the ameloblastomas (E–G) but failed to be detected in the CCOC (H). Some ameloblastomas, as shown for ameloblastoma 4, also express the transcript in the mesenchymal part (G, arrow).