Figure 1.

A-B-C. Levels of circulating Treg cells (CD4+CD25+FoxP3+) in the blood of melanoma patients during the four weeks of HDI IV induction therapy. The peripheral blood assays have been performed at the start of each week of treatment (Day 0, 8, 15, 22) and after the last week (on Day 29). (A) Trend in a single patient; (B) trend of the average value of Treg cells during HDI IV treatment; (C) Boxplot summarizing the data observed in the cohort of patients during the initial 4 weeks of treatment.