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Recent evidence for indirect immunomodulatory mechanisms of HDI
| Increase in Tumor Infiltrating cells36 |
| Development of autoantibodies and clinical manifestations of autoimmunity (~30%)37,38 |
| Decrease in Circulating Treg cells51 |
| Modulation of the STAT1/STAT3 balance in tumor cells and host lymphocytes52 |
| Change in serum cytokine concentrations53 |
| Normalization of T cell STAT 1 signaling defects in peripheral blood lymphocytes54 |
