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. Author manuscript; available in PMC: 2009 Dec 19.
Published in final edited form as: Neurosci Lett. 2008 Oct 14;448(1):157–160. doi: 10.1016/j.neulet.2008.10.025

Figure 2.

Figure 2

D1 receptor-mediated suppression of evoked action potentials is attenuated in NAc neurons in f/fc-fos-D1-cre (mutant) mice. (A) D1 receptor stimulation reduces evoked firing of NAc neurons (n=8) in wild-type mice. (B) The inhibitory effects of D1 receptor stimulation on evoked spikes (n=9 neurons) are attenuated in NAc neurons in f/fc-fos-D1-cre mice. (C) D1 receptor-mediated inhibition is abolished in NAc neurons of f/fc-fos-D1-cre mice. There is a significant attenuation in suppression of evoked firing by SKF38393 in NAc neurons in f/fc-fos-D1-cre mice compared to that in wild-type mice (F1,14=8.59; p < 0.05, *Newman-Keuls test, p < 0.05). (D) Depolarization of the resting membrane potential (RMP) induced by SKF38393 is significantly attenuated in NAc neurons of f/fc-fos-D1-cre mice as compared to wild-type mice (Student's t-test, *p < 0.05).