TABLE 2.

Weighted average cost per day and mean duration of initial drug therapy

			CAB/FLU
	Voriconazole		CAB	FLU
	IV	Oral	IV	IV	Oral
Dose (mg/kg)	3–6	200–400	1	400	400
Weighted average cost per day ($)	411–709	93	71	73	22
Mean duration of initial drug therapy (days)
Completed initial therapy
Toxicity	12.8	7.3	6.5	6.8	7.3
No toxicity	11.3	8.5	5.3	7.4	6.7
Discontinued initial therapy
Due to toxicity	7.4	1.2	3.2	1.4	0.8
Due to lack of efficacy or other	11.5	4.0	4.7	5.0	3.0
Died during active treatment	8.0	0.4	4.5	4.2	0.2

The base-case analysis assumes that any unused drug remaining after administration was discarded. Because conventional amphotericin B (CAB) is indicated for several conditions other than candidemia, a sensitivity analysis was performed, in which any unused CAB remaining after administration was recycled for future use. Because the base-case analysis assumes any unused CAB remaining after administration was discarded, the choice between using a CAB dose of 0.7 mg/kg or 1.0 mg/kg is of negligible importance. Under both dosing scenarios, the weighted average number of vials required for each patient is two vials per day. FLU Fluconazole; IV Intravenous