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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: J Neurochem. 2009 Jan;108(1):190–201. doi: 10.1111/j.1471-4159.2008.05751.x

Figure 5. Leptin facilitates fast inhibitory transmission via a PI 3-kinase-driven process.

Figure 5

A,B, Leptin-induced facilitation of eIPSCs is PI 3-kinase-dependent. A, Plot of the pooled data of amplitude of normalized eIPSCs against time during whole cell dialysis with wortmannin (50 nM). Below the plot are representative synaptic currents obtained from an individual experiment in the presence of wortmannin (1), in the combined presence of wortmannin and leptin (2), and following washout of leptin (3). B, Histogram of the pooled data illustrating the relative changes in eIPSC amplitude in control conditions, in the presence of leptin and following its washout, for neurones dialysed with wortmannin. C, D, Inhibition of pre and postsynaptic PI 3-kinase facilitates leptin induced I-LTD. C, Plot of the pooled data illustrating the amplitude of normalized eIPSCs against time from slices bathed in wortmannin (50 nM). Below the plot are representative synaptic current traces obtained in the presence of wortmannin (1), in the combined presence of wortmannin and leptin (2), and following washout of leptin (3). D, Histogram of the pooled data of normalised eIPSC amplitude in control conditions, in the presence of leptin and following its washout, in slices incubated with wortmannin