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. 2008 Dec 26;283(52):36257–36264. doi: 10.1074/jbc.M806786200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — In situ hybridization analysis of Fgf10 and its upstream transcriptional regulators in TβRII^Δ/Δ and control lungs. A, whole mount (panels a, b, e, and f) and section (panels c, d, g, and h) in situ hybridization. Note expansion and increased Fgf10 expression in TβRII^Δ/Δ (panels e–h) compared with TβRII^fl/fl (panels a–d) lungs. Scale bar, 2.2 mm (panels a and c); 1 mm (panels b and d); 100 μm (panels e–h). B, section in situ hybridization for Foxf1 (panels a and d), Tbx5 (panels b and e), and Tbx4 (panels c and f) in TβRII^Δ/Δ and TβRII^fl/fl (control) E15.5 lungs. Scale bar, 100 μm. C, quantification of Foxf1 and Tbx4 mRNA by real-time PCR. Values are fold induction or repression, compared with TβRII^fl/fl controls (arbitrarily adjusted to 1). p value, 0.004.