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A model for human Maf1 involvement in repression of RNA polymerase III. A, efficient repression of transcription by Maf1 is achieved by preventing RNA pol III recruitment to promoter-bound TFIIIB and TFIIIC. B, once RNA pol III is recruited into PICs or transcription is initiated and the polymerase is stalled at TCs, Maf1 is unable to inhibit multiple round transcription mediated by facilitated recycling.
