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(A) S1PL+/+ lung: Alveolar spaces are generally clear and septa are thin in Wt mice (B) S1PL−/− lung: Alveoli contain variably sized irregularly shaped polygonal flakes and clumps of smooth homogenous (hyaline) material accompanied by increased numbers of alveolar macrophages. Alveolar septa are mildly thickened due to cellular hypertrophy and collagen deposition. H&E stain.
