Table 2.

Clinical response data and correlation with p53R2 molecular response

Patient	Age/Sex	Diagnosis	Clinical Response	p53R2 mRNA induction1	p53R2 protein induction2
1	83F	MDS	Stable disease	Yes	Yes
2	82M	MDS	Stable disease	Yes	Yes
3	73M	MDS	Stable disease	Yes	No
4	77F	MDS	Failure	n/d	No
5	65M	MDS	Failure	No	Yes
6	70M	MDS	Stable disease	Yes	Yes
7	79M	AML	Failure	n/d	Yes
8	70M	MDS	Partial remission	Yes	Yes
9	69F	AML	Failure	No	No
10	72F	MDS	Failure	No	n/d
11	75M	MDS	Failure	No	n/d
12	68M	AML	Failure	No	n/d
13	70M	MDS	Stable disease	No	n/d
14	72F	AML	Marrow complete remission	Yes	n/d
15	47F	CMML	Stable disease	Yes	n/d
Correlation with Clinical Response (Fisher’s exact test)				P=0.0047	P=0.5238

¹4-fold or greater p53R2 induction in bone marrow cells over pre-treatment at ≥1 post-treatment time point

²1.5-fold or greater p53R2 induction in bone marrow cells over pre-treatment at ≥1 post-treatment time point

n/d = no data