TABLE 1.

Ethical principles impacting research in children

Beneficence	Applying evidence-based care generated from research specific to children
Nonmaleficence	Avoiding harmful therapies extrapolated from adult patient data or experience
Distributive justice	Allowing research benefits to be available to all populations
Respect for informed consent	Supporting developing autonomy in children considering research participation
Respect for privacy and confidentiality	Providing confidentiality within the limits of legal requirements