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. Author manuscript; available in PMC: 2008 Dec 22.
Published in final edited form as: J Neurochem. 2008 Nov 10;107(6):1753–1765. doi: 10.1111/j.1471-4159.2008.05745.x

Fig. 3. Attenuation of κ opioid-induced stimulation of ERK1/2 phosphorylation by PTX in type-1 immortalized astrocytes.

Fig. 3

A. Effect of PTX on U69,593 signaling. Cells were transiently transfected with KOR cDNA, serum starved for 24 h in the presence of 100 ng/mL PTX and treated with 1 μM U69,593 for the indicated time intervals and ERK1/2 phosphorylation was assayed. N=4-10 *p< 0.05, **p< 0.01 vs. control; †p< 0.05, vs. U69,593 alone at the same time point. B. Lack of effect of PTX on MOM-Sal-B signaling. Cells were transiently transfected with KOR cDNA, serum starved for 24 h in the presence of 100 ng/mL PTX and treated with 1 μM MOM-Sal-B for the indicated time intervals and ERK1/2 phosphorylation was assayed. N=4-11. ***p< 0.001 vs. control.