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. Author manuscript; available in PMC: 2008 Dec 22.
Published in final edited form as: Ann Biomed Eng. 2008 Oct 7;36(12):2134–2148. doi: 10.1007/s10439-008-9575-z

FIGURE 5.

FIGURE 5

Heparinase Treatment reduces receptor binding for FGF-2 and HB-EGF (simulations). Simulations were performed using “non-receptor-coupling” model under 4 °C conditions (no synthesis or internalization of receptors or HSPG) and growth factor bound to receptor at 2.5 h under normal (□) and heparinase (■) conditions are shown. Simulations for (a) used 5 ng/mL or 0.28 nM FGF-2, 0.42 nM HB-EGF, and 0.83 nM EGF as used experimentally in Fig. 3. Receptor-bound FGF-2 as a function of FGF-2 treatment is shown for normal (□) and heparinase (■) conditions in (b).