Figure 1.

Tumor growth in the RBP-J^-/- and control mice. (A) LLC, H22, S180, and B16 tumor cells (5 x 10⁶) were injected subcutaneously into the RBP-J^-/- and RBP-J^+/- mice. Tumors were dissected 15 days after the inoculation and were photographed; representative tumors were shown. (B) Tumor weight index (ratio of tumor weight-body weight) was compared on day 15 after the tumor inoculation. (C) Tumor volume. Tumor volume was monitored every 2 days from the seventh day after the inoculation, by measuring tumor length (L) and short (S) with a sliding caliper. Tumor volume = L x S² x 0.51. Bars, means ± SD. *P < .05. n = 3 in LLC; n = 3 in S180; n = 5 in H22; and n = 5 in B16.