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Biotin (vitamin B7 or vitamin H) is a cofactor for CO2 transfer. (a) The carboxyl terminus of biotin is linked to the amino group of a specified lysine residue by an amide bond. Carboxylating enzymes using biotin are: acetyl-CoA carboxylase alpha; acetyl-CoA carboxylase beta; methylcrotonyl-CoA carboxylase; propionyl-CoA carboxylase; and pyruvate carboxylase. (b) An example of the use of biotin in the carboxylation of pyruvate by pyruvate carboxylase.
