FIG. 3.

Whole-body insulin sensitivity and tissue-specific glucose uptake in vivo in the SMLPL^−/− and control mice. A: Steady-state whole-body glucose infusion rate during hyperinsulinemic-euglycemic clamps and hepatic insulin action as the percent suppression of basal hepatic glucose production during the clamps for young SMLPL^−/− mice. n = 5 for both SMLPL^−/− and control mice. B: Steady-state whole-body glucose infusion rate during hyperinsulinemic-euglycemic clamps for old SMLPL^−/− mice. n = 5 for both SMLPL^−/− and control mice. C: Tissue-specific glucose uptake. Insulin-stimulated glucose uptake in skeletal muscle (gastrocnemius, SM), WAT, brown adipose tissue (BAT), and heart were measured by injecting a bolus of 2-[¹⁴C]-DG during the clamp. n = 5 for SMLPL^−/− and n = 6 for control mice. D: Insulin-stimulated glucose transport in soleus muscle of SMLPL^−/− mice (n = 3 for both SMLPL^−/− and control mice). DPM, disintegrations per minute.