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. 2009 Jan;58(1):185–193. doi: 10.2337/db08-1150

FIG. 4.

FIG. 4.

Set7/9 knockdown in mouse islets. Male C57BL/6J mice were administered intraperitoneal injections of stabilized siRNAs as described in research design and methods. A: Confocal microscopic imaging of representative islets isolated from mice injected with either unlabeled control siRNA or Cy3-labeled control siRNA. The panel shows islets imaged upon excitation at 488 nm (autofluorescence of islet β-cells) and the same islets imaged upon excitation at 595 nm (corresponding to the Cy3 label). B: Male C57BL/6J mice were injected intraperitoneally with stabilized control siRNA or siRNAs against Set7/9 (siSet1 and siSet2). Shown are immunoblots of islet, brain, liver, and muscle extracts from siRNA-injected mice for Set7/9 and actin. (Please see http://dx.doi.org/10.2337/db08-1150 for a high-quality digital representation of this figure.)