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. 2009 Jan;58(1):2–11. doi: 10.2337/db08-9027

TABLE 1.

How combination therapies will help in translating antigen-specific immunotherapy to induce Tregs

1. Enhancing efficacy while reducing unwanted systemic side effects
2. Choosing the correct islet antigen
3. Choosing the right dose of antigen
4. Choosing optimal time for intervention = identifying ideal target group (pre-diabetic, recent onset)