TABLE 1.

Plasma free fatty acid levels; arterial blood lactate, alanine, and glycerol levels; and net hepatic balance in 18-h–fasted conscious dogs during the basal (−40 to 0 min) and experimental (0–240 min) periods

	Basal period	Experimental period (min)
	−40 to 0	60	120	180	210	240
Plasma free fatty acid level (μmol/l)
Control	924 ± 69	245 ± 54	117 ± 23	115 ± 27	147 ± 48	124 ± 39
Vildagliptin	736 ± 118*	111 ± 23	88 ± 26	71 ± 25	82 ± 31	66 ± 15
Blood glycerol level (μmol/l)
Control	97 ± 6	42 ± 9	28 ± 4	31 ± 5	35 ± 6	32 ± 6
Vildagliptin	70 ± 9*	21 ± 4*	24 ± 4	20 ± 5	19 ± 4	16 ± 2
Net hepatic glycerol uptake (μmol · kg−1 · min−1)
Control	1.7 ± 0.1	0.8 ± 0.2	0.5 ± 0.1	0.6 ± 0.2	0.6 ± 0.2	0.6 ± 0.2
Vildagliptin	1.6 ± 0.3	0.5 ± 0.2	0.5 ± 0.1	0.4 ± 0.2	0.5 ± 0.2	0.3 ± 0.1
Blood lactate level (μmol/l)
Control	482 ± 81	534 ± 71	536 ± 89	545 ± 66	593 ± 72	564 ± 59
Vildagliptin	433 ± 87	571 ± 82	535 ± 83	555 ± 63	543 ± 49	551 ± 68
Net hepatic lactate balance (μmol · kg−1 · min−1)
Control	−4.5 ± 0.7	2.4 ± 1.7	1.1 ± 0.8	0.3 ± 1.2	0.7 ± 0.9	1.5 ± 1.1
Vildagliptin	−2.3 ± 2.7	5.4 ± 2.4	2.1 ± 1.6	3.2 ± 1.7	2.5 ± 1.7	3.2 ± 1.9
Blood alanine level (μmol/l)
Control	289 ± 24	261 ± 23	239 ± 16	230 ± 14	235 ± 16	225 ± 15
Vildagliptin	300 ± 33	275 ± 24	245 ± 13	217 ± 18	221 ± 21	219 ± 24
Net hepatic alanine uptake (μmol · kg−1 · min−1)
Control	2.2 ± 0.2	1.5 ± 0.2	1.7 ± 0.1	2.1 ± 0.2	2.0 ± 0.1	2.2 ± 0.3
Vildagliptin	2.3 ± 0.4	1.8 ± 0.2	2.0 ± 0.5	2.2 ± 0.2	2.4 ± 0.2	2.5 ± 0.3

Data are means ± SE; n = 6 per group;

^*P < 0.05.