TABLE 2. Adjusted Odds Ratio and 95% CI for Associations between Selected Variables and Risk of HPV16 Associated SCCOP.
| Characteristic | HPV16 status | Cases (n = 188) | Controls (n = 349) | Adj. OR* (95% CI) | ||
|---|---|---|---|---|---|---|
| No. | ( %) | No. | ( %) | |||
| All subjects | - | 101 | 53.7 | 306 | 87.7 | 1.0 |
| + | 87 | 46.3 | 43 | 12.3 | 5.98 (3.89-9.20) | |
| p73 genotype | ||||||
| GC/GC | - | 64 | 56.1 | 187 | 87.0 | 1.0 |
| + | 50 | 43.9 | 28 | 13.0 | 5.47 (3.14-9.54) | |
| GC/AT+AT/AT | - | 37 | 50.0 | 119 | 88.8 | 1.0 |
| + | 37 | 50.0 | 15 | 11.2 | 7.96 (3.83-16.5) | |
| Age (years) | ||||||
| ≤ 55 | - | 50 | 47.6 | 152 | 88.4 | 1.0 |
| + | 55 | 52.4 | 20 | 11.6 | 7.94 (4.26-14.8) | |
| > 55 | - | 51 | 61.5 | 154 | 87.0 | 1.0 |
| + | 32 | 38.5 | 23 | 13.0 | 4.21 (2.25-7.88) | |
| Sex | ||||||
| Male | - | 80 | 51.6 | 239 | 87.9 | 1.0 |
| + | 75 | 48.4 | 33 | 12.1 | 6.65 (4.09-10.8) | |
| Female | - | 21 | 63.6 | 67 | 87.0 | 1.0 |
| + | 12 | 36.4 | 10 | 13.0 | 4.06 (1.51-10.9) | |
| Smoking | ||||||
| Never | - | 27 | 42.9 | 97 | 90.6 | 1.0 |
| + | 36 | 57.1 | 10 | 9.4 | 13.8 (5.91-32.1) | |
| Ever | - | 74 | 59.2 | 209 | 86.4 | 1.0 |
| + | 51 | 40.8 | 33 | 13.6 | 4.34 (2.59-7.27) | |
| Alcohol use | ||||||
| Never | - | 18 | 47.4 | 84 | 90.3 | 1.0 |
| + | 20 | 52.6 | 9 | 9.7 | 14.9 (5.24-42.4) | |
| Ever | - | 83 | 55.3 | 222 | 86.7 | 1.0 |
| + | 67 | 44.7 | 34 | 13.3 | 4.79 (2.96-7.75) | |
*
HPV positive versus HPV negative in each stratum; OR were adjusted for age, sex, smoking and alcohol use accordingly in logistic regression models.