TABLE 3. Stratification of Risk of SCCOP in Never and Ever Smokers/Drinkers by p73 Genotype and HPV16 Status.
| Smoking & drinking status & p73 genotype | HPV16 status | Cases | Controls | Crude OR (95%CI) | Adj.* OR (95%CI) |
|---|---|---|---|---|---|
| No. (%) | No. (%) | ||||
| Never smokers | (n = 63) | (n = 107) | |||
| GC/GC | - | 12 (19.1) | 57 (53.3) | 1.0 | 1.0 |
| + | 24 (38.0) | 8 (7.4) | 14.3 (5.17-39.3) | 14.6 (5.24-40.5) | |
| GC/AT+AT/AT | - | 15 (23.8) | 40 (37.4) | 1.78 (0.75-4.21) | 1.66 (0.68-4.08) |
| + | 12 (19.1) | 2 (1.9) | 28.5 (5.63-144.2) | 28.6 (5.53-148.2) | |
| Ever smokers | (n = 125) | (n = 242) | |||
| GC/GC | - | 52 (41.6) | 130 (53.7) | 1.0 | 1.0 |
| + | 26 (20.8) | 20 (8.3) | 3.25 (1.67-6.32) | 3.35 (1.71-6.55) | |
| GC/AT+AT/AT | - | 22 (17.6) | 79 (32.6) | 0.70 (0.39-1.23) | 0.67 (0.38-1.19) |
| + | 25 (20.0) | 13 (5.4) | 4.81 (2.29-10.1) | 4.43 (2.09-9.42) | |
| Never drinkers | (n = 38) | (n = 91) | |||
| GC/GC | - | 12 (31.6) | 55 (60.4) | 1.0 | 1.0 |
| + | 16 (42.1) | 6 (6.6) | 12.2 (3.96-37.7) | 13.7 (4.27-43.8) | |
| GC/AT+AT/AT | - | 6 (15.8) | 29 (31.9) | 0.95 (0.32-2.79) | 0.98 (0.32-3.00) |
| + | 4 (10.5) | 1 (1.1) | 18.3 (1.88-179.0) | 23.1 (2.01-265.4) | |
| Ever drinkers | (n = 150) | (n = 258) | |||
| GC/GC | - | 52 (34.7) | 132 (51.2) | 1.0 | 1.0 |
| + | 34 (22.7) | 22 (8.5) | 3.92 (2.10-7.33) | 3.83 (2.04-7.21) | |
| GC/AT+AT/AT | - | 31 (20.6) | 90 (34.9) | 0.87 (0.52-1.47) | 0.86 (0.50-1.45) |
| + | 33 (22.0) | 14 (5.4) | 5.98 (2.96-12.1) | 5.55 (2.73-11.3) |
*
Adjusted for age, sex, and drinking/smoking in logistic regression models.