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. 2008 Oct 15;75(1):208–217. doi: 10.1124/mol.108.048314

Fig. 2.

Fig. 2.

YC-1 stimulates HO-1 mRNA expression and promoter activity in vascular SMCs. A, time course of HO-1 mRNA expression after the administration of YC-1 (50 μM). B, concentration-dependent increase in HO-1 mRNA after the administration of YC-1 (5-100 μM for 24 h). C, effect of actinomycin D (ActD; 2 μg/ml) and cycloheximide (CX; 5 μg/ml) on YC-1 (50 μM for 8 h)-mediated increase in HO-1 mRNA. D, effect of YC-1 (10-100 μM for 24 h) on HO-1 promoter activity. HO-1 mRNA expression is expressed in arbitrary units (a.u.). Results are means ± S.E.M. of three to five experiments. *, statistically significant effect of YC-1.