Fig. 7.

YC-1 enhances cytokine-mediated NO synthesis and iNOS protein expression in vascular SMCs. A, effect of YC-1 (10-50 μM) on nitrite accumulation after the treatment of cells with a cytokine mixture (CM) consisting of interleukin-1β (5 ng/ml) and tumor necrosis factor-α (20 ng/ml) for 24 h. B, effect of YC-1 (10-50 μM) on iNOS protein expression aftertreatment of cells with a CM consisting of interleukin-1β (5 ng/ml) and tumor necrosis factor-α (20 ng/ml) for 24 h. iNOS protein is expressed in arbitrary units (a.u.). Results are means ± S.E.M. of four to six experiments. ^*, statistically significant effect of CM. †, statistically significant effect of YC-1.