Skip to main content
. 2008 Oct 15;75(1):208–217. doi: 10.1124/mol.108.048314

Fig. 9.

Fig. 9.

8-Br-cGMP and BAY 41-2272 enhance cytokine-mediated NO synthesis and iNOS protein expression in vascular SMCs. A, effect of 8-Br-cGMP (100-500 μM) on nitrite accumulation after the treatment of cells with a cytokine mixture (CM) consisting of interleukin-1β (5 ng/ml) and tumor necrosis factor-α (20 ng/ml) for 24 h. B, effect of BAY 41-2272 (5-20 μM) on nitrite accumulation after the treatment of cells with a CM consisting of interleukin-1β (5 ng/ml) and tumor necrosis factor-α (10 ng/ml) for 24 h. C, effect of 8-Br-cGMP (200 μM) or BAY 41-2272 (20 μM) on iNOS protein expression after treatment of cells with a CM consisting of interleukin-1β (5 ng/ml) and tumor necrosis factor-α (20 ng/ml) for 24 h. iNOS protein is expressed in arbitrary units (a.u.). Results are means ± S.E.M. of four to six experiments. *, statistically significant effect of CM. †, statistically significant effect of 8-Br-cGMP or BAY41-2272.