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. 2009 Jan;133(1):69–77. doi: 10.1085/jgp.200810049

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© 2009 Wang et al.

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Figure 4. — Representative current traces of G551D-CFTR (A) and G551C-CFTR (B) in the presence of different [Cd²⁺]. The Cd²⁺ dose–response relationships for G551D-CFTR (C) and G551C-CFTR (D) were fitted with the Hill equation, y = min + (max−min)/ [1+ (K_1/2/[x])ⁿ)] (smooth curves). The fold increase of the current in the presence of Cd²⁺ was normalized to the maximal fold increase for each mutant (G551D: 21.38 ± 4.19-fold, 100 μM Cd²⁺; G551C: 7.4 ± 0.3, 10 μM Cd²⁺). G551D: K_1/2 = 14.6 ± 6.3 μM and n = 1.03 ± 0.34; G551C: K_1/2 = 3.29 ± 0.66 μM and n = 1.89 ± 0.52.