Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Jan;133(1):111–127. doi: 10.1085/jgp.200810154

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2009 Yu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — Comparison of the different transepithelial transport routes. Transcellular/transmembrane channels (left) mediate ion transport (arrow) perpendicular to the plane of the lipid bilayer (gray), with the pore wall formed predominantly by intramembrane domains of the channel polypeptide (orange). Paracellular pores such as claudins (right) mediate transport parallel to and extracellular to the lipid bilayer, with the pore walls presumably constituted by the extracellular domains of claudin polypeptides.