Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Jan;133(1):111–127. doi: 10.1085/jgp.200810154

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2009 Yu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 10. — Evidence that aspartate-65 is an electrostatic cation interaction site. (A) Effect of D65N on permeability to Ca²⁺, as measured by radiotracer flux assay. (B) Effect of acidification to pH 4.0 on P_Na of WT and mutant claudin-2. (C and D) Absolute and relative permeabilities to alkali metal cations of WT and mutant claudin-2 (see B for explanation of symbols). (E) Relative permeability to Li⁺ (P_Li/P_Na) of WT or D65N claudin-2 at pH 7.0 or 4. *, P < 0.01; **, P < 0.001 compared with WT at pH 7.0 (n = 6–9).