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. 2009 Jan;133(1):111–127. doi: 10.1085/jgp.200810154

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© 2009 Yu et al.

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Figure 5. — Characteristics of the WT claudin-2 pore conductance. (A) Conductance scanning to distinguish the effect of claudin-2 on transcellular from paracellular conductance. Transcellular conductance was determined by scanning above the cell body, and paracellular conductance was determined by scanning over the lateral cell border (TJ). Results show the mean of 12–15 conductance measurements per site performed on two filters each. (B) Relationship between transepithelial voltage (V) and the current (I) carried by claudin-2. (C) Relationship between extracellular Na⁺ activity and claudin-2 conductance. Na⁺ concentration was adjusted by isosmotic replacement of NaCl with mannitol.