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. 2009 Jan;133(1):111–127. doi: 10.1085/jgp.200810154

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© 2009 Yu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — Effect of charge-neutralizing mutations in the first extracellular domain on claudin-2 permeability. (A and B) Conductance and Na⁺ and Cl⁻ permeability of claudin-2 WT (WT) and mutants (TM = E53Q, D65N, and D76N). *, P < 0.001 compared with WT. (C) Arrhenius plot showing the relationship between conductance (log scale) and the reciprocal of the absolute temperature (T). (D) Activation energies (E_a) for conductance and permeability to Na⁺ and Li⁺, determined by linear regression from Arrhenius plots. *, P < 0.05; **, P < 0.01.