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. 2009 Jan;133(1):43–58. doi: 10.1085/jgp.200810004

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© 2009 Zhang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Effects of the charged mutations, K519M and K519E, on the apparent K_1/2 of the CPA block. Data points were obtained at a membrane voltage of −140 mV. The apparent K_1/2's for various E127/K519 combinatorial mutants in the background of the E166C mutation are given in Table II.