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. 2008 Dec 29;183(7):1243–1257. doi: 10.1083/jcb.200807130

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© 2008 Nagao et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Involvement of p53 in Myc- and p19^ARF-dependent regulation of NSCs. (A and B) Forebrain neurospheres derived from p53^+/+, p53^+/−, and p53^−/− embryos were infected with control, p19^ARF, and dn-Myc viruses and were subsequently subjected to the self-renewal (A) and differentiation (B) assays as described in Figs. 2 and 3. (C) Model for the relationships between Myc, p19^ARF, and p53. *, P < 0.01 compared with control virus–infected culture with the same genotypes; ^$, P < 0.01 compared with WT (+/+) cells infected with the same viruses. Error bars indicate mean + SD.