Figure 9. TTR tetramer stabilization by inhibitors monitored by circular dichroism in 6M urea.

Influence of small molecule inhibitors diflunisal (1a, 7,2 µM DIF) and iododiflunisal (1b, 7,2 µM IDIF) on the rate of wtTTR (3,6 µM) (left) and mutant Y78FTTR (3,6 µM) (right) dissociation in 6M urea measured by Far-UV CD circular dichroism as a function of time.