Table 1. Energy values (in kcal/mol) of the minima points of affinity grids regions corresponding to HBPs in the A–A′ binding site of TTR:T₄ complex after removing T₄ and water molecules (see materials and methods section for details).

	HBP1-HBP1′	HBP2-HBP2′	HBP3-HBP3′
F	−1.3	−3.2	−5.6
Cl	−3.1	−6.7	−7.1
Br	−5.0	−8.5	−9.6
I	−6.2	−9.4	−11.4