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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Drug Discov Today Dis Models. 2008;5(1):13–18. doi: 10.1016/j.ddmod.2008.07.002

Table 1. Comparison of astrocytic Ca2+ dynamics models.

In vitro models In vivo models In silico models
Pros

  • Study (sub)cellular components of astrocytic Ca2+ dynamics

  • Study astrocytic modulation of synapses

  • Assess effect on behavior

  • Study disease model in whole organism

  • Generates predictions that can be tested
Cons

  • Abnormal expression of proteins in culture

  • Live imaging limited to superficial layers of cortex

  • Needs to be revised with new empirical evidence
Best use of model

  • Study Ca2+ dynamics of single cells

  • Study disease model in whole organism

  • Provides framework for future experiments
How to get access to the model

  • Literature, academic supplier

  • Literature, academic supplier

  • Literature, academic supplier
Relevant patent n/a n/a n/a
Refs [11-18,20-22,25-29,34,37-40] [15,17,18,30-32,40] [33,35,36]