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Scheme of UVB triggered CSF-1 and Mø mediated apoptosis during cutaneous lupus in MRL-Faslpr mice. 1) UVB induces CSF-1 expression in keratinocytes. 2) BMMø are recruited by CSF-1 to sites rich in CSF-1 in the skin (eg, keratinocytes). 3) CSF-1 activates Mø that release mediators and 4) induce apoptosis of adjacent cells (eg, keratinocytes).
