Figure 3.

Effect of etomidate on firing rate of thalamic neurons. Raster plots of timing of action potentials are shown for 100 neurons during waking and at 0.5 μM, 1 μM and 2 μM etomidate. Etomidate action was modeled using phasic and tonic inhibition. Note that increasing etomidate concentration results in decreased number of thalamic neuronal action potentials, although the thalamic firing rate was less affected than cortical firing rate (Figure 2).