Table 1.

Cortical and Thalamic firing rates (Hz) during combined phasic and tonic GABAergic inhibition

Etomidate	Layer 4 Exc	Layer 4 Inh	Infragran Exc	Infragran Inh	Supragran Exc	Supragran Inh	NRT	Thalamic Exc	Thalamic Inh
0	5.6 ± 0.02	13.90 ± 0.03	6.4 ± 0.03	13.78 ± 0.02	2.85 ± 0.04	12.07 ± 0.05	3.63 ± 0.02	10.57 ± 0.02	5.60 ± 0.01
0.25	4.38 ± 0.02	11.85 ± 0.01	5.31 ± 0.01	11.77 ± 0.02	1.63 ± 0.02	8.64 ± 0.03	2.70 ± 0.02	10.40 ± 0.03	5.47 ± 0.02
0.5	3.62 ± 0.02	10.33 ± 0.02	4.52 ± 0.02	10.29 ± 0.02	1.02 ± 0.01	6.55 ± 0.05	2.16 ± 0.01	9.96 ± 0.01	5.27 ± 0.01
0.75	3.01 ± 0.01	9.07 ± 0.02	3.83 ± 0.01	9.04 ± 0.02	0.63 ± 0.02	4.95 ± 0.01	1.76 ± 0.01	9.51 ± 0.04	5.04 ± 0.01
1	2.51 ± 0.02	7.97 ± 0.02	3.27 ± 0.01	7.92 ± 0.02	0.39 ± 0.01	3.75 ± 0.01	1.45 ± 0.01	8.98 ± 0.02	4.79 ± 0.03
1.5	1.75 ± 0.01	6.12 ± 0.01	2.32 ± 0.01	6.07 ± 0.01	0.13 ± 0.01	2.03 ± 0.02	0.98 ± 0.01	7.94 ± 0.01	4.30 ± 0.02
2	1.17 ± 0.01	4.64 ± 0.01	1.58 ± 0.02	4.58 ± 0.01	0.04 ± 0.01	0.96 ± 0.02	0.64 ± 0.01	6.90 ± 0.01	3.82 ± 0.01

Data (impulses/sec, Hz) are expressed as grand mean, standard deviation (from 4 simulations) of the mean firing rate of 1600 neurons in each cortical layer and thalamus, except for 900 neurons in NRT. Simulated etomidate concentrations are μM. Exc = excitatory; Inh = inhibitory; Infragran = infragranular layer; Supragran = supragranular layer; NRT= reticular nucleus.