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Model for role of protein phosphatase PP1 in establishment of DNA methylation. Unknown regulatory factor(s) recruit the catalytic subunit PP1 to the chromatin causing dephosphorylation of H3S10. This permits methylation of H3K9 by DIM-5. HP1 recognizes and binds this trimethyl mark, setting the stage for subsequent events that lead to methylation of DNA by DIM-2. Open ovals indicate putative unknown factors in various complexes.
