Table 2.
Sensitivity (%) | Specificity (%) | Concordance (%) | |
---|---|---|---|
Reproductive toxicity | |||
Teratogenic risk | 50.2 | 91.3 | 79.3 |
Rodent dominant lethal | 41.3 | 95.2 | 75.9 |
Drosophila m. SLRL | 73.9 | 88.1 | 81.6 |
Endocrine disruption | |||
Estrogen αreceptor binding | 77.3 | 86.5 | 82.5 |
Estrogen reporter gene | 46.4 | 94.9 | 80.9 |
Androgen receptor antagonism* | 64.4 | 84.2 | 76.1 |
Note: The androgen receptor antagonism model was also validated by prospective external validation, where a validation set was chosen after the model had been constructed by randomly choosing test chemicals within the applicability domain. The chemicals were double blinded and tested in our laboratory. The external validation with 102 chemicals resulted in a sensitivity of 57%, a specificity of 98%, and a concordance of 92% of the model [14].