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. 2008 Sep 22;155(8):1224–1234. doi: 10.1038/bjp.2008.360

Figure 2.

Figure 2

Competition curves for various antagonists in mouse cerebral cortex. (a and b) Competition curves for prazosin and RS-17053 at 500 pM [3H]-silodosin-binding sites in the intact segments and membranes of the WT mouse cortex. (c) Competition curves for silodosin and BMY 7378 at 500 pM [3H]-prazosin-binding sites in the intact segments of the WT mouse cortex. (d) Competition of silodosin in the intact segments of AKO, BKO, and DKO mouse cortices at 500 pM [3H]-prazosin-binding sites. Each curve is representative of similar results obtained in 2–5 experiments. AKO, α1A-adrenoceptor gene knockout; BKO, α1B-adrenoceptor gene knockout; DKO, α1D-adrenoceptor gene knockout; WT, wild type.